Waning Immunogenicity and Vaccine Failure

How do we know when a vaccine is no longer effective?  When the vaccine type is isolated from the wild-type, they are set on different evolutionary trajectories, in very different environments.  We are studying the expected and realized patterns of molecular evolution in immunoepitopes of pathogens for which vaccines are available to calculate the molecular shelf-life of specific vaccines on the market. 

This is a collaboration between Dr. James Lyons-Weiler and Dr. Wakefield.and is expected to lead to a publication submitted for peer reviewin 2019.

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Click on any of the images of the preliminary results* from the forthcoming publication to donate.  These results are preliminary because we are checking and double-checking our calculations, assumptions and resulting estimates.