IPAKPress Releases
Sept 1, 2015: IPAK Launch Press Release
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About Dr. Lyons-Weiler
Dr. Lyons-Weiler has seventeen years' experience in biomedical research, serving primarily in the capacity of research study design and analysis. His primary interests are in the development of prediction models of adverse outcomes of biomedical treatments, therapies, and biologic prophylatics and in the molecular and cellular basis of disease. He was the Founding Editor-in-Chief of the open-access journal Cancer Informatics, and has served on the editorial board of numerous journals. His latest journal, Science, Public Health Policy, & the Law, brings forward views and analyses of the goodness of fit between public health and medical practices and science.
Dr. Lyons-Weiler has served as an expert witness in cases involving vaccine injury.
Research Publications
Lyons-Weiler, J 2018. Autism is an Acquired Cellular Detoxification Syndrome with Genetic Heterogeneity. Autism Open Access 8(1):1-15.
Lyons-Weiler, J and R. Ricketson. 2018. Reconsideration of the Immunotherapeutic Pediatric Safe Dose Levels of Aluminum. Journal and Trace Elements in Medicine and Biology 48:67-73.
Dobrowolski SF, Lyons-Weiler J, Spridik K, Vockley J, Skvorak K, Biery A. 2016. DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAHenu2 mouse model of phenylketonuria. Mol Genet Metab. pii: S1096-7192(16)30001-4. doi: 10.1016/j.ymgme.2016.01.001. PMID 26822703.
Dobrowolski SF, Lyons-Weiler J, Spridik K, Biery A, Breck J, Vockley J, Yatsenko S, Sultana T. Altered DNA methylation in PAH deficient phenylketonuria. Mol Genet Metab. 115(2-3):72-7. doi: 10.1016/j.ymgme.2015.04.002. PMID: 25990862.
Ozburn AR, Falcon E, Twaddle A, Nugent AL, Gillman AG, Spencer SM, Arey RN, Mukherjee S, Lyons-Weiler J, Self DW, McClung CA. 2014 Direct Regulation of Diurnal Drd3 Expression and Cocaine Reward by NPAS2. Biol Psychiatry. 2014 Aug 13. pii: S0006-3223(14)00594-0. doi: 10.1016/j.biopsych.2014.07.030. PMID: 25444159.
Zubenko GS, Hughes HB 3rd, Jordan RM, Lyons-Weiler J, Cohen BM. 2014. Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 165(6):457-66. doi: 10.1002/ajmg.b.32257. PMID:
25059218.
Dobrowolski, SF, A. Biery, K Sprydik, E. Kranik, K. Skvorak, J. Vockley, J. Lyons-Weiler, T. Sultana. 2014. Methylome repatterning in a mouse model of Maternal PKU Syndrome. Molecular Genetics and Metabolism 113(3):194-9. doi: 10.1016/j.ymgme.2014.08.006.
Shin SS, Bales JW, Yan HQ, Kline AE, Wagner AK, Lyons-Weiler J, Dixon CE. 2013. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats. J Neurotrauma. 30:259-70. PMID 23094804
Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A. 2012. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun. 425:873-9. PMID 22902635
Hsu E, Shi H, Jordan RM, Lyons-Weiler J, Pilewski JM, Feghali-Bostwick CA. 2011. Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension. Arthritis Rheum. 63:783-94. PMID 21360508
Founds SA, Shi H, Conley YP, Jeyabalan A, Roberts JM, Lyons-Weiler J. 2012. Variations in discovery-based preeclampsia candidate genes. Clin Transl Sci. 5:333-9. PMID 22883611
Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, Baty CJ, Gibson GA, Erdos G, Wang Z, Milosevic J, Tkacheva OA, Divito SJ, Jordan R, Lyons-Weiler J, Watkins SC, Morelli AE. 2012. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 119:756-66. PMID 22031862.
Hsu E, Shi H, Jordan RM, Lyons-Weiler J, Pilewski JM, Feghali-Bostwick CA. 2011. Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension. Arthritis Rheum. 63:783-94. PMID 21360508
Sultana, T., R. Jordan & J. Lyons-Weiler. 2009. Optimization of the use of consensus methods for the detection and putative identification of peptides via mass-spectrometry using protein standard mixtures. J. of Proteomics & Bioinformatics 2:262-273. PMID 19779596 http://www.omicsonline.com/ArchiveJPB/2009/June/02/JPB2.262.html
Davies, M.L., S. Xu, J. Lyons-Weiler, A. Rosendorff, L.R. Wasil; S.A. Webber, D. Metes, D.T. Rowe. 2011. Cellular factors associated with latency and spontaneous Epstein-Barr virus reactivation in B-lymphoblastoid cell lines. Virology 400:53-67. PMID 20153012
Additional recent publications of importance to the field (in chronological order)
Dagda RK, Sultana T, Lyons-Weiler J. 2010. Evaluation of the consensus of four peptide identification algorithms for tandem mass spectrometry based proteomics. J Proteomics & Bioinformatics 3:39-47. PMID 20589240.
Founds SA, Conley YP, Lyons-Weiler JF, Jeyabalan A, Allen Hogge W, Conrad KP. 2009. Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta. 30:15-24. PMID19027158
Ranganathan S, Polshyna A, Lutka F, Nicholl G, Lyons-Weiler J, and Bowser R. Assessment of protein stability in cerebrospinal fluid by mass spectrometry based proteomics. Clinical Proteomics 2:91-101. http://www.springerlink.com/content/81778847577u8h73/ PMID 20200596
Lyons-Weiler, J, S Patel and S Bhattacharya. 2003. A classification-based machine learning approach for the analysis of genome-wide expression data. Genome Research 13:503-512. PMID 12618382
Bhattacharya, S, D Long, J Lyons-Weiler. 2004. Overcoming confounded controls in the analysis of gene expression data from microarray experiments. Applied Bioinformatics 2:197-208. PMID 15130791
Patel, S, J Lyons-Weiler. 2004. caGEDA: A web application for the integrated analysis of global gene expression patterns in cancer. Applied Bioinformatics 3:49-62. PMID 16323966
Lyons-Weiler, J, S Patel, MJ Becich and T Godfrey. 2004. Tests for finding complex patterns of differential expression in cancer: towards individualized medicine. BMC Bioinformatics,5:110. PMID 15307894
Lyons-Weiler, J, R Pelikan, HJ Zeh, III, DC Whitcomb, DE Malehorn, WL Bigbee, and M Hauskrecht. 2005. Assessing the statistical significance of the achieved classification error of classifiers constructed using serum peptide profiles, and a prescription for random sampling repeated studies for massive high-throughput genomic and proteomic studies. Cancer Informatics 1(1) 53-77. PMID19325865
Shi H, Lyons-Weiler J. 2007. Clinical decision modeling system. BMC Med Inform Decis Mak. Aug 13;7(1):23. PMID17697328
Jordan R, Patel S, Hu H, and Lyons-Weiler J. 2008. Efficiency analysis of competing tests for finding differentially expressed genes in lung adenocarcinoma. Cancer Informatics, 6: 389-421. http://www.la-press.com/journal.php?journal_id=10&issue_id=101 PMID 19259419
Berty, H.P., H. Shi & J. Lyons-Weiler. 2010. Determining the statistical significance of survivorship prediction models. J. Clinical Evaluation 16:155-165.
