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The Nucleic Acid Amplification Testing Evaluation Consortium (NAATEC)

Founded: 1/1/2021

Principle Investigator: Dr. James Lyons-Weiler, PhD, Director and Scientific Director

NAATEC is an international collaboration of scientists and doctors conducting research on the evaluation of qRT-PCR testing and other nucleic acid detection techniques used in the diagnosis of pathogens such as the SARS-CoV-2 virus.

Our goal for 2024-2025 is to evaluate the accuracy, sensitivity, and specificity of PCR-testing as implemented in the diagnosis of COVID19 and influenza.

Our goals and abilities go beyond this list, however, the specific studies will include:

-Independent empirical evaluation of the accuracy, sensitvity and specificity of qRT-PCR protocols in clinical samples suspected of containing whole or partial genomes of the SARS-CoV-2 virus.

-Independent empirical assessment of the presence of other respiratory pathogens in samples diagnosed as confirmed or suspected COVID19 cases.

-Determination of the likely correct viral status of patient samples using sequencing-based technologies.

Proposal status: SUBMITTED

IRB Approval: APPROVED

Funding requested: $50,000

Join Us in Revolutionizing Diagnostic Testing: Support Dr. Sin Han Lee’s Groundbreaking Work

The IPAK NAATEC Consortium is proud to announce our latest initiative, a transformative project aimed at developing the most accurate and reliable diagnostic test for distinguishing between H1N1 and H5N1 influenza viruses. We are seeking your support to fund Dr. Sin Han Lee, a renowned expert in molecular diagnostics, as he embarks on creating a sequence-based test that will set a new standard in the field.

Why This Project Matters:

The global health landscape is fraught with challenges, not least of which is the accurate and timely diagnosis of viral infections. Influenza viruses, particularly H1N1 and H5N1, continue to pose significant threats to public health worldwide. The ability to rapidly and accurately distinguish between these strains is crucial for effective treatment and containment measures. However, current diagnostic tests often suffer from limitations, including the risk of false positives, which can lead to misdiagnosis and inappropriate public health responses.

Our Solution:

Dr. Sin Han Lee’s innovative approach is poised to change the game. He is developing a sequence-based test that will not only distinguish between H1N1 and H5N1 with unprecedented precision but will also be engineered to suffer zero false positives. This test will leverage the latest advancements in molecular sequencing to ensure that every diagnosis is accurate and actionable. The implications for public health are profound—accurate diagnostics will enable better patient outcomes, more effective use of resources, and more targeted public health interventions.

Why We Need Your Support:

Developing a test of this caliber requires significant investment in research, development, and validation. The IPAK NAATEC Consortium is committed to supporting this groundbreaking work, but we need your help to bring it to fruition. By contributing to this project, you are not only supporting cutting-edge science but also making a tangible impact on global health. Your donation will directly fund the resources, equipment, and expert personnel needed to develop this life-saving diagnostic tool.

The Impact of Your Contribution:

Accurate Diagnosis: Help ensure that patients receive the right treatment quickly, reducing the spread of influenza and saving lives.
Global Health Security: Support the development of a diagnostic tool that can prevent misdiagnosis and improve public health responses worldwide.
Innovation in Science: Be part of a project that sets a new standard for diagnostic accuracy, with zero tolerance for false positives.

Join Us in Making a Difference:

Your contribution will make a lasting impact on the future of diagnostic testing and global health. Together, we can support Dr. Sin Han Lee in his mission to develop a test that will not only distinguish between H1N1 and H5N1 but also achieve the highest standard of diagnostic accuracy—zero false positives.

Donate today and be a part of this groundbreaking initiative.

For more information or to make a contribution, please visit [insert donation link] or contact us directly at [insert contact information].

Together, we can change the future of diagnostics.

Consortium Members

Publications

Lee, SH. Testing for SARS-CoV-2 in cellular components by routine nested RT-PCR followed by DNA sequencing. Int. J Geriat and Rehac 2:69-96. http://www.int-soc-clin-geriat.com/info/wp-content/uploads/2020/03/Dr.-Lees-paper-on-testing-for-SARS-CoV-2.pdf

Lyons-Weiler, 2020. Balance of Risk in COVID-19 Reveals the extreme cost of the false positives. Intern J Vacc Theor, Pract, Research 1(2):209-222. https://ijvtpr.com/index.php/IJVTPR/article/view/15

Lyons-Weiler, J. 2020. Lyons-Weiler, J. 2020. Plan B public health infrastructure and operations oversight reform for America. Intl J Vacc Theor, Pract, Research 1(2):283-294. https://ijvtpr.com/index.php/IJVTPR/article/view/19

Ealy, H. M . McEvoy, J Nowicki, M Sava and N Ruggles. 2021. An Evidence-Based Position Paper to Ensure Ethical Conduct. (444 pages) 3/26/2021 - Executive Summary and full Report available online at GreenMedInfo

In the Press:

Half of CDC Coronvirus Test Kits Are Inaccurate Study Finds - MSN.com

CDC Coronavirus Test Kits Generate 30% False Positive and 20% False Negative Results - Connecticut Pathologist’s Newly Published Findings Confirm - Business Wire